Question Of The Day: Mood, Adjustment, and Dementia Disorders

Q. A nurse is monitoring a client receiving tranylcypromine sulfate (Parnate). Which serious adverse reaction can occur with high dosages of this monoamine oxidase (MAO) inhibitor?

A. Hypotensive episodes
B. Hypertensive crisis
C. Muscle flaccidity
D. Hypoglycemia


Correct Answer: B

Explanation: The most serious adverse reaction associated with high doses of MAO inhibitors is hypertensive crisis, which can lead to death. Although not a crisis, orthostatic hypotension is also common and may lead to syncope with high doses. Muscle spasticity (not flaccidity) is associated with MAO inhibitor therapy. Hypoglycemia isn't an adverse reaction of MAO inhibitors.